Expansion and preservation of the functional activity of adult hematopoietic stem cells cultured ex vivo with a histone deacetylase inhibitor.

Zimran E, Papa L, Djedaini M, Patel A, Iancu-Rubin C. Hoffman R. Stem Cells Transl Med. 2020 Jan.

Pre-clinical development of a cryopreservable megakaryocytic cell product capable of sustained platelet production in mice

Patel A, Clementelli CM, Jarocha D, Mosoyan G, Else C, Kintali M, Fong H, Tong J, Gordon R, Gillespie V, Keyzner A, Poncz M, Hoffman R, Iancu-Rubin C. Transfusion. 2019 Dec.

Ex Vivo Expansion of Hematopoietic Stem Cells from Human Umbilical Cord Blood-derived CD34+ Cells Using Valproic Acid

Papa L, Djedaini M, Hoffman R. J Vis Exp. 2019 Apr 11;(146).

Mitochondrial Role in Stemness and Differentiation of Hematopoietic Stem Cells

Papa L, Djedaini M, Hoffman R. Stem Cells Int. 2019 Feb 6;2019:4067162. Review.

Ex vivo HSC expansion challenges the paradigm of unidirectional human hematopoiesis

Papa L, Djedaini M, Hoffman R. Ann NY Acad Sci. 2019 Jun 14. Review.

Whirling Platelets Away for Transfusion

Iancu-Rubin C, Hoffman R, Migliaccio AR. Cell. 2018 Jul 26;174(3):503-504.

Ex vivo human HSC expansion requires coordination of cellular reprogramming with mitochondrial remodeling and p53 activation

Papa L, Zimran E, Djedaini M, Ge Y, Ozbek U, Sebra R, Sealfon SC, Hoffman R. Blood Adv. 2018 Oct 23;2(20):2766-2779.

Imetelstat, a telomerase inhibitor, differentially affects normal and malignant megakaryopoiesis

Mosoyan G, Kraus T, Ye F, Eng K, Crispino JD, Hoffman R, Iancu-Rubin C. Leukemia. 2017 Nov;31(11):2458-2467.

Role of epigenetic reprogramming in hematopoietic stem cell function

Iancu-Rubin C, Hoffman R. Curr Opin Hematol. 2015 Jul;22(4):279-85. Review.

Epigenetic reprogramming induces the expansion of cord blood stem cells

Chaurasia P, Gajzer DC, Schaniel C, D’Souza S, Hoffman R. J Clin Invest. 2014 Jun;124(6):2378-95.

Down-regulation of stathmin expression is required for megakaryocyte maturation and platelet production

Iancu-Rubin C, Gajzer D, Tripodi J, Najfeld V, Gordon RE, Hoffman R, Atweh GF. Blood. 2011 Apr 28;117(17):4580-9.

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